The golden tickseed improves insulin resistance

A study conducted by a group of researchers from the Chinese Academy of Medical Sciences and Peking Union Medical College and China Academy of Chinese Medical Sciences showed that the golden tickseed (Coreopsis tinctoria) has the ability to improve insulin resistance. This study, which was published in Chinese Herbal Medicines, looked into the effect of the ethyl acetate extract of C. tinctoria on the insulin resistance of rats fed with a high-fat diet.

• The test specimens used for this study were male Sprague-Dawley (SD) rats fed with a high-fat diet, with 60 percent of the diet consisting of fats.
• Consumption of a high-fat diet led to insulin resistance in the rats. This was indicated by a significant increase in blood glucose, insulin, total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels.
• Ethyl acetate extracts of C. tinctoria were given to the mice for eight weeks.
• Metabolic levels of high glucose-treated cells, control cells, and marein-treated cells were analyzed using a metabolomic experiment.

The results of the study show that ethyl acetate extracts of C. tinctoria can improve insulin resistance by ameliorating glucose metabolism disorders. This happens by increasing glucose uptake and glycogen synthesis and reducing phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase) protein levels.

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Journal Reference:

Jiang B-P, Lv Q-Y, Xiang J-M, Le L, Hu K-P, Xu L-J, Xiao P-G. INHIBITION OF METABOLIC DISORDERS IN VIVO AND IN VITRO BY MAIN CONSTITUENT OF COREOPSIS TINCTORIA. Chinese Herbal Medicines. 2018;10(2):157–168. DOI:10.1016/j.chmed.2018.03.004